Helminth Excretory/Secretory Proteins Ameliorate Colitis Through Preservation of Intestinal Homeostasis - PubMed
3 hours ago
- #Gut Homeostasis
- #Helminth Proteins
- #Inflammatory Bowel Disease
- Emu-ESP from Echinococcus multilocularis alleviates DSS-induced colitis in mice by preserving intestinal homeostasis.
- The protein mitigates gut microbiota dysbiosis, enhances mucosal barrier function through increased mucin and junction gene expression, and reduces apoptosis and NF-κB signaling.
- Emu-ESP promotes macrophage polarization to the M2 phenotype, suggesting anti-inflammatory and immunomodulatory effects beneficial for treating inflammatory bowel diseases.