cGAS-STING Signaling Pathway in Urogenital Oncology: Regulation, Resistance, and Routes to Response - PubMed
3 days ago
- #immunotherapy
- #urogenital oncology
- #cGAS-STING pathway
- The cGAS-STING pathway connects cytosolic DNA sensing to innate immunity and plays a critical role in urogenital cancers.
- Regulation of the pathway involves phosphorylation, ubiquitination, epigenetic repression, and metabolic reprogramming.
- Therapeutic strategies include exploiting genomic instability, reactivating STING signaling, and using engineered microbes or synthetic cyclic dinucleotides.
- Combining cGAS-STING activation with immune checkpoint blockade shows synergy but also reveals resistance mechanisms.
- Biomarkers and patient-derived models are aiding clinical translation of cGAS-STING-targeted therapies.
- Non-canonical signaling and intercellular cGAMP transport influence therapeutic responses and vulnerabilities.