Cellular senescence in neurodegenerative diseases: a bibliometric analysis and mechanistic synthesis linking translational pathways to therapeutic implications - PubMed
3 hours ago
- #senotherapeutics
- #neurodegenerative-diseases
- #cellular-senescence
- Cellular senescence is a key driver in neurodegenerative diseases (NDs) like Alzheimer's (AD) and Parkinson's (PD).
- Key mechanisms include p16INK4A/p53-p21CIP1 pathways and senescence-associated secretory phenotype (SASP).
- Bibliometric analysis of 269 articles (2002-2025) shows increasing research interest, led by the US, China, and Italy.
- Prominent institutions include Chinese Academy of Sciences and University of Texas System.
- Leading authors are Lorenz Studer, Judith Campisi, and Julie K. Andersen.
- Research hotspots focus on tau protein dysregulation and senescent microglia in neuroinflammation.
- Multi-target senomorphics targeting SASP emerge as promising therapeutic strategies.
- Future priorities include biomarker development and targeted interventions for senescent cells.