Single-cell RNA sequencing and spatial transcriptomics reveal heterogeneity and key subgroups in ovarian cancer: HOXA1 identified as a potential therapeutic biomarker - PubMed
9 hours ago
- #ovarian-cancer
- #single-cell-RNA-sequencing
- #biomarker
- Single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) were used to study ovarian cancer (OC).
- Key tumor subgroup C4 SAA1+ tumor cells were identified, mainly found in untreated OC patients.
- HOXA1 was identified as a key transcription factor (TF) and potential therapeutic biomarker in OC.
- A prognostic model, SAA1+ Tumor Cells Risk Score (STRS), was developed to assess risk groups.
- The study provides insights into OC heterogeneity, prognosis, and potential therapeutic targets.