Creatine plus β-Hydroxy-β-Methylbutyrate supplementation is associated with preserved glutathione redox-balance and redox-function associations in older adults: a secondary analysis of a randomized cr

2 days ago

Combined creatine and β-Hydroxy-β-Methylbutyrate (HMB) supplementation may help preserve glutathione redox-balance in older adults.
The study involved 30 physically active older adults (62.7 ± 5.3 years) in a randomized, double-blind, placebo-controlled crossover trial.
Participants received either 3 g/day creatine + 3 g/day calcium HMB or placebo during supervised exercise training for 6-week phases.
Primary endpoints included oxidized glutathione levels and the Glutathione Redox Index.
Supplementation showed nominal preservation of redox balance, though effects were not significant after false discovery rate (FDR) adjustment.
In men, a nominal increase in malondialdehyde was observed under supplementation.
Exploratory analyses suggested weak associations between changes in redox indices and functional measures.
The study supports further investigation in larger trials to confirm redox-function associations.

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