Phased ERK responsiveness and developmental robustness regulate teleost skin morphogenesis - PubMed
8 days ago
- #ERK dynamics
- #zebrafish epidermis
- #cell division
- Phased ERK responsiveness regulates teleost skin morphogenesis.
- Oriented cell divisions facilitate early periderm growth in zebrafish.
- ERK activity predicts cell cycle entry and regulates cell cycling dynamics.
- ERK activity transitions to promote hypertrophic cell growth as development proceeds.
- Genetic blockade of cell division results in oversized periderm cells without impairing development.
- Stage-dependent differential responsiveness to ERK signaling and developmental robustness in teleost skin.