Aspartate availability drives differential engagement of the malate-aspartate shuttle - PubMed
3 hours ago
- #mitochondrial metabolism
- #aspartate
- #malate-aspartate shuttle
- The malate-aspartate shuttle transfers reducing equivalents from the cytosol to mitochondria.
- Aspartate availability determines the engagement of the malate-aspartate shuttle in cells.
- Increasing aspartate availability enhances the use of the shuttle and mitochondrial metabolism of glucose-derived pyruvate.
- During differentiation, elevated flux through the shuttle enables fueling of mitochondrial networks from glucose-derived carbon.
- Engineering aspartate demand can reverse metabolic signatures of differentiated cells.
- Cell-state-specific aspartate demand influences shuttle use and mitochondrial substrate preferences during differentiation.