Disruption of the circadian rhythm induces acute pancreatitis via amino acid metabolism-mediated macrophage infiltration - PubMed
3 hours ago
- #Amino Acid Metabolism
- #Macrophage Infiltration
- #Circadian Rhythms
- Circadian rhythm disruption is linked to a higher risk of pancreatitis, as shown in a UK Biobank cohort study.
- In a mouse model, continuous light exposure increased acinar vacuolization, trypsin levels, and M1 macrophage infiltration in the pancreas.
- RNA-seq analysis revealed enrichment of amino acid metabolism genes, especially in glycine, serine, and threonine pathways, under circadian disruption.
- Inhibition of threonine dehydrogenase (TDH) with QC1 promoted M2 macrophage polarization, and melatonin treatment reduced TDH expression and inflammation.