RNA-binding motif protein 15 promotes gastric cancer growth and drug resistance via USP10-mediated deubiquitination and stabilization of nuclear NRF2 - PubMed
5 days ago
- #NRF2
- #Gastric Cancer
- #Chemotherapy Resistance
- RNA-binding motif protein 15 (RBM15) is upregulated in gastric cancer (GC) cells and promotes tumor growth and chemoresistance.
- RBM15 recruits USP10 to the nucleus, where it deubiquitinates and stabilizes NRF2, reducing its degradation.
- The RBM15-USP10-NRF2 axis drives resistance to cisplatin and 5-FU in GC cells.
- Disrupting this pathway sensitizes GC cells to chemotherapy and suppresses tumor growth.
- RBM15 serves as both a predictive biomarker and therapeutic target for overcoming chemotherapy resistance in GC.