A Review of Post-Inflammatory Pigmentation Changes: Pathophysiology, Diagnosis and Treatment - PubMed
3 hours ago
- #dermatology
- #hyperpigmentation
- #skin of colour
- Post-inflammatory hyperpigmentation (PIH) and hypopigmentation result from dermatoses, skin injury, infections, or allergic reactions.
- PIH pathophysiology involves UV radiation, skin inflammation, and cytokine/growth factor signaling between skin cells.
- PIH is diagnosed clinically and can persist for months to years, impacting quality of life.
- Patients with skin of colour (Fitzpatrick III-VI) are at higher risk and experience more pronounced dyspigmentation.
- Management includes photoprotection, topical agents (hydroquinone, retinoids), light/laser therapies, and chemical peels.
- High-level clinical evidence for PIH treatments remains limited.