Control of microglial dynamics by the Arp2/3 complex and the autism- and schizophrenia-associated protein CYFIP1 - PubMed
7 hours ago
- #neuropsychiatric-disease
- #actin-remodeling
- #microglia
- Microglia use dynamic branched processes to sense and respond to their environment.
- The Arp2/3 complex is crucial for maintaining microglial morphology and surveillance but not chemotaxis.
- CYFIP1, linked to autism and schizophrenia, is highly expressed in microglia and affects their morphology and surveillance.
- Deletion of Cyfip1 reduces microglial complexity and increases lysosome volume and synapse engulfment.
- Actin remodeling by CYFIP1 and Arp2/3 influences microglial dynamics, potentially impacting neuropsychiatric diseases.