Pan-Immune-Inflammation Value for Mortality Risk Stratification in Critically Ill Patients With Acute Ischemic Stroke: A Cohort Study Based on the MIMIC-IV Database - PubMed
a day ago
- #inflammatory markers
- #mortality risk stratification
- #acute ischemic stroke
- The study explores the association between pan-immune-inflammation value (PIV) and all-cause mortality (ACM) in critically ill patients with acute ischemic stroke (AIS).
- A retrospective cohort study of 710 ICU patients from the MIMIC-IV database found that each 1000-unit increase in PIV was independently associated with an 8% higher risk of 90-day ACM.
- A reverse L-shaped nonlinear correlation was observed with a threshold PIV value of 2987.61, above which mortality rates were significantly higher (52.7% vs. 28.3%).
- Subgroup analyses showed a stronger association between PIV and ACM in patients without sepsis.
- Sensitivity analyses confirmed the robustness of the findings, which were consistent for 30-day and 1-year ACM.
- PIV serves as a tool for ACM risk stratification in critical AIS, showing a reverse L-shaped relationship with short- and long-term mortality.