Lipid droplet dynamics in metabolic regulation - PubMed
10 hours ago
- #metabolic regulation
- #organelle dynamics
- #lipid droplets
- Lipid droplets (LDs) are dynamic organelles that store neutral lipids and play a key role in metabolic regulation.
- LD dynamics involve biogenesis, growth, remodeling, and catabolism, linked to pathways like β-oxidation and lipogenesis.
- Dysregulation of LD dynamics is associated with metabolic diseases such as obesity, liver disease, and cancer.
- LDs interact physically and functionally with other organelles including mitochondria, peroxisomes, ER, and lysosomes.
- Tissue-specific LD biology in adipose, liver, muscle, pancreatic β-cells, and immune cells influences systemic energy homeostasis.
- Advanced techniques like fluorescent probes, lipidomics, and imaging enable visualization and manipulation of LDs.
- Therapeutic targeting of LD dynamics offers potential for treating metabolic disorders and drug delivery applications.