Mussel-inspired adhesive hydrogel reprograms osteoimmune niche for robust bone regeneration in complex defects - PubMed
4 hours ago
- #immunomodulation
- #bone-regeneration
- #hydrogel
- Mussel-inspired adhesive hydrogel (DPG@MA) developed for bone regeneration in complex defects.
- Hydrogel features dynamic cross-linking with DOPA-pectin conjugate and GelMA for stable adhesion.
- Incorporates alendronate-loaded mesoporous silica nanoparticles (MA) for sustained release of silicon ions and alendronate.
- Promotes macrophage polarization from pro-inflammatory M1 to pro-healing M2 phenotype.
- Enhances bone regeneration and osseointegration in rat models, outperforming Novabone®.
- Offers integrated functionality of interfacial adhesion, immunomodulation, and osteogenesis.