A transcription regulator atlas identifies TOX3 as an Atoh1 coactivator in cerebellar development and tumorigenesis - PubMed
3 hours ago
- #medulloblastoma
- #TOX3
- #cerebellar development
- A comprehensive atlas profiles 1,904 transcription regulators in multiple organs of mice across different developmental stages.
- TOX3 is identified as a coactivator of Atoh1 in cerebellar granule neuron progenitors (GNPs).
- Tox3-deficient mice exhibit severe ataxia, cerebellar hypoplasia, and impaired primary cilia due to GNP depletion.
- TOX3 is highly expressed in subsets of medulloblastoma, and its deletion reduces tumorigenesis in a mouse model.
- TOX3 physically associates with Atoh1, enhancing transcriptional activation by up to 120-fold at shared regulatory elements.
- Cross-species comparisons link Tox3 expression to cerebellum expansion during vertebrate evolution.
- The study provides a valuable resource for exploring novel transcriptional regulators in organogenesis and disease.