Sialic acid exacerbates polycystic ovary syndrome in mice by modulating gut microbiota-mediated bile acid metabolism and FXR activation - PubMed
8 hours ago
- #PCOS
- #gut microbiota
- #bile acid metabolism
- Sialic acid (Neu5Ac) worsens polycystic ovary syndrome (PCOS) in mice by affecting gut bacteria and bile acid metabolism.
- Neu5Ac increases growth of gut bacteria Ligilactobacillus salivarius, which breaks down conjugated bile acids like TUDCA.
- Reduced TUDCA levels lead to higher activation of the intestinal FXR receptor, which decreases IL-22 production.
- IL-22 normally helps protect against ovarian ferroptosis by activating the STAT3 signaling pathway.
- The findings suggest a pathway linking sialic acid, gut microbiota, bile acids, FXR, and IL-22 in PCOS development, pointing to potential new treatments.