Integrin β1 Demarks Precursors of Brain-Residing Antibody-Secreting Cells in Multiple Sclerosis - PubMed
5 days ago
- #Antibody-Secreting Cells
- #Integrin β1
- #Multiple Sclerosis
- Integrin β1 (CD29) is identified as a key marker for CXCR3+ memory B cells in blood, which are precursors to antibody-secreting cells (ASCs) in the CNS of multiple sclerosis (MS) patients.
- CD29+CXCR3+ memory B cells show a higher propensity to cross the blood-brain barrier and differentiate into ASCs when aided by T-cell help.
- In MS patients, CD29 and CXCR3 coexpression is found in ASCs derived from CSF, meninges, and brain tissue, suggesting a role in CNS inflammation.
- Treatment with natalizumab and cladribine affects CD29 levels on CXCR3+ memory B cells, indicating CD29 as a potential marker for monitoring treatment responses in MS.
- The study suggests CD29 could serve as a prognostic tool for predicting the efficacy of high-efficacy MS therapies.