Hospital outbreak sustained by Klebsiella pneumoniae sequence type 147 co-producing NDM-1 and OXA-48, Rome, Italy, February to March 2025: molecular tracing and control measures - PubMed
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- #antibiotic resistance
- #Klebsiella pneumoniae
- #hospital outbreak
- Hospital outbreak of carbapenemase-producing Klebsiella pneumoniae in Rome, Italy (Feb-Mar 2025).
- 10 patients colonized/infected with NDM-1 and OXA-48 co-producing strains in critical care units.
- 9 cases were hospital-acquired, detected via rectal swab screening.
- Infection prevention measures (cohorting, cleaning, surveillance) initially contained transmission.
- Outbreak spread across wards, highlighting challenges in isolation and patient movement.
- Environmental sampling found one contaminated surface with the outbreak strain.
- Molecular typing (NanoTyping and WGS) confirmed clonal spread of high-risk ST147 clone.
- Phylogenetic analysis linked the outbreak to regional dissemination of ST147.
- Emphasizes need for genomic surveillance, rapid diagnostics, and strict IPC protocols.
- Enhanced screening and routine surveillance critical in high MDRO prevalence settings.