Ginseng root extract alleviates nonalcoholic fatty liver disease by modulating mitochondrial function and regulating lipid metabolism via the AMPK pathway - PubMed
3 hours ago
- #NAFLD
- #Ginseng Extract
- #Mitochondrial Function
- Ginseng root extract (GRE) reduces lipid accumulation and reactive oxygen species in a free fatty acid-induced NAFLD model.
- GRE improves mitochondrial function by reducing oxidative stress, lipid peroxidation, and membrane transition pore permeability.
- It activates the AMPK pathway, suppressing lipogenic genes and enhancing fatty acid catabolism.
- GRE's protective effects against NAFLD-related apoptosis and cell cycle disruptions are mediated via AMPK activation.
- The study highlights GRE as a promising natural therapeutic for NAFLD by targeting mitochondrial function and lipid metabolism.