Genetic inactivation of TRPM4 does not alter the temperature-dependent movement of mouse microglia - PubMed
4 hours ago
- #TRP channels
- #Microglia
- #Thermosensitivity
- Genetic inactivation of TRPM4 does not affect temperature-dependent movement in mouse microglia.
- Microglia are CNS immune cells involved in brain homeostasis and immune surveillance.
- Previous research identified TRPV4 as a key thermosensitive ion channel in microglial motility.
- CRISPR/Cas9 was used to create functional Trpm4-knockout (TRPM4KO) mice.
- Time-lapse imaging showed no change in temperature-dependent motility in TRPM4KO microglia.
- TRPM4 is not essential for temperature-dependent microglial motility.