Loss of VMP1 Impairs Tight Junction Recycling and Aggravates Intestinal Barrier Dysfunction in Inflammatory Bowel Disease - PubMed
3 hours ago
- #VMP1
- #IBD
- #tight junction
- VMP1 is significantly downregulated in Inflammatory Bowel Disease (IBD) and correlates with disease severity.
- VMP1 deficiency disrupts tight junction integrity in intestinal epithelial cells, increasing permeability and exacerbating inflammation.
- VMP1 facilitates CORO1C recruitment to late endosomes, promoting Retromer-mediated recycling of Occludin to the plasma membrane.
- Impairment of VMP1 shifts Occludin trafficking toward ESCRT-dependent microautophagic degradation, leading to sustained loss of tight junctions.
- The study identifies VMP1 as a novel regulator of epithelial tight junction recycling and barrier homeostasis, offering potential therapeutic insights for IBD.