Bioorthogonal Click-Engineered Microneedle Patch Enables Adeno-Associated Virus-Mediated Dermal Acidic Fibroblast Growth Factor Expression for Hair Loss Treatment - PubMed
3 hours ago
- #gene therapy
- #hair regeneration
- #microneedle patch
- A bioorthogonal click-engineered microneedle patch (ClickMNP) was developed for hair loss treatment.
- ClickMNP delivers adeno-associated virus encoding acidic fibroblast growth factor (AAV-aFGF) for sustained expression.
- The patch uses dibenzocyclooctyne-modified hyaluronic acid (HA-DBCO) and azide-functionalized poly(lactide-co-glycolide) (PLGA-N3) for cross-linking.
- ClickMNP enhances hair-follicle regeneration, dermal angiogenesis, and prolongs the anagen phase in murine models.
- The platform shows biocompatibility and upregulates pathways related to fibroblast proliferation and angiogenesis.
- ClickMNP offers a transformative solution combining chemical engineering with gene therapy for hair loss.