Unanchored by two hits: IFNγ and mechanical stress synergize to undermine melanocyte adhesion and promote vitiligo - PubMed
4 hours ago
- #IFNγ
- #vitiligo
- #melanocyte adhesion
- Study reveals IFNγ and mechanical stress reduce FAK and ITGβ1, weakening melanocyte adhesion to the basement membrane.
- Findings show decreased FAK and ITGβ1 in vitiligo patient skin, linking to the Koebner phenomenon in disease progression.
- Baricitinib treatment reduces melanocyte detachment by targeting a cathepsin L-dependent pathway.