Increased expression of TRIM69 in peripheral blood from systemic lupus erythematosus and its clinical significance - PubMed
5 hours ago
- #Biomarker
- #Systemic Lupus Erythematosus
- #TRIM69
- TRIM69 expression is significantly elevated in systemic lupus erythematosus (SLE) patients compared to healthy controls (HC) and rheumatoid arthritis (RA) groups.
- Serum TRIM69 levels correlate strongly with clinical features of SLE and show discriminatory ability in ROC analysis.
- A predictive model combining serum TRIM69, hemoglobin (HGB), and neutrophil-to-lymphocyte ratio (NLR) effectively distinguishes SLE from HC with high accuracy (AUC = 0.941).
- The model maintains consistency in an independent validation cohort (AUC = 0.931) and correlates with SLE disease activity.
- TRIM69 may play a role in SLE pathogenesis, and the predictive model could serve as a bioindicator for disease forecast and progression.