Persistent microglial activation following neonatal CMV infection mediates neurodegeneration - PubMed
12 hours ago
- #CMV
- #microglia
- #neurodegeneration
- Neonatal CMV infection leads to adult-onset neurodegeneration in the retina and brain.
- Persistent activation of microglia plays a key role in mediating neurodegeneration post-infection.
- Transient depletion of activated microglia before pathology onset can repopulate the tissue with reparative microglia, preserving neuron density.
- Early-life MCMV infection results in dysfunctional microglia that drive neurodegeneration without viral reactivation.
- The study highlights the long-term neurological impacts of congenital CMV infections.