Maternal microbiome-derived propionate regulates offspring myelination via histone lactylation - PubMed
12 hours ago
- #microbiome
- #epigenetics
- #myelination
- Maternal gut microbiome influences offspring neurodevelopment through microbial metabolites.
- Propionate (PA), a short-chain fatty acid (SCFA), regulates oligodendrocyte precursor cell (OPC) differentiation via histone H4K12 lactylation (H4K12la).
- Maternal antibiotic-induced gut dysbiosis causes hypomyelination in offspring, reversible with postnatal PA supplementation.
- PA enhances both developmental myelination and remyelination after demyelination by promoting OPC differentiation.
- PA activates the cGMP-PKG pathway and upregulates Sox family transcription factors crucial for oligodendrocyte differentiation.
- Findings suggest a PA-H4K12la-cGMP-PKG pathway linking maternal microbiome to offspring myelination, offering potential treatments for demyelinating disorders.