Sulforaphane improved cognitive behavior in APP/PS1 mice via promoting structural and functional synaptic plasticity in the hippocampus - PubMed
3 hours ago
- #Alzheimer's disease
- #Synaptic plasticity
- #Sulforaphane
- Sulforaphane (SFN) improved cognitive behavior in APP/PS1 mice by enhancing synaptic plasticity in the hippocampus.
- SFN administration reduced oxidative damage caused by Aβ₁����₂ and improved spatial learning and memory deficits in AD mice.
- Bioinformatics analysis indicated SFN modulates synapse-related pathways linked to Alzheimer's disease.
- Electrophysiological recordings showed SFN alleviated hippocampal long-term potentiation (LTP) impairment.
- SFN increased synaptic protein expression (PSD-95, synaptophysin) and enhanced dendritic complexity and spine density in the hippocampal CA1 region.
- The study supports SFN's neuroprotective role in AD by restoring synaptic structural integrity and function.