The BAFF/APRIL system at the crossroads of B cell memory and autoimmune relapse: Implication into the therapeutic strategies - PubMed
3 hours ago
- #BAFF-APRIL-system
- #B-cell-memory
- #Autoimmune-therapies
- BAFF and APRIL regulate B cell subsets via receptors BCMA, TACI, and BAFFR, influencing differentiation and survival.
- Humoral memory relies on long-lived plasma cells (LLPCs) and memory B cells (MBCs), formed with or without germinal centers.
- The BAFF/APRIL system sustains memory reservoirs, contributing to autoimmune relapse by maintaining autoreactive antibody pools.
- Targeted therapies like belimumab, telitacicept, and BCMA CAR-T cells offer new options for treatment-resistant autoimmune cases.
- BAFF/APRIL targeting addresses LLPC survival, complementing conventional B cell depletion for sustained immunological control in autoimmune diseases.