Neutrophil extracellular traps in the tumor microenvironment, metastasis, therapy, and beyond: advances, challenges, and perspectives - PubMed
2 hours ago
- #Immunotherapy
- #Cancer Biology
- #Tumor Microenvironment
- Neutrophil extracellular traps (NETs) released in the tumor microenvironment influence cancer progression, metastasis, immune regulation, and therapy response.
- NETs promote tumorigenesis by causing DNA damage and inducing epithelial-mesenchymal transition (EMT).
- NETs facilitate metastasis through trapping circulating tumor cells, remodeling the pre-metastatic niche, and reactivating dormant cells.
- NETs contribute to an immunosuppressive tumor microenvironment by modulating T cells, NK cells, and macrophages.
- NETs mediate resistance to treatments, including chemotherapy, radiotherapy, and immunotherapy.
- Targeting NETs, via inhibition of PAD4 or neutrophil elastase or degradation with DNase I, is a potential therapeutic strategy to enhance existing cancer therapies.