Beyond Cholesterol Lowering: Clinical Caution, Personalization, and Nutritional Integration in Statin Therapy - PubMed
7 hours ago
- #statin therapy
- #cardiovascular disease
- #nutritional status
- Elevated LDL-C is a major risk factor for atherosclerosis and CVD, with statins being the cornerstone for LDL-C reduction.
- Statin effectiveness in primary prevention for low-to-moderate risk individuals is controversial, and long-term adherence is often limited by adverse effects.
- 20-30% of high-risk or secondary prevention patients do not achieve meaningful benefits despite adequate LDL-C lowering.
- Over half of statin-treated patients discontinue therapy within two years, primarily due to adverse effects, without increased cardiovascular mortality.
- Malnutrition and sarcopenia may influence statin pharmacokinetics and pharmacodynamics, affecting therapeutic response and adverse event susceptibility.
- Statin-induced lipid lowering can alter nutrition-related biomarkers, potentially leading to misclassification of malnutrition.
- Statin prescription should be individualized and patient-centered, integrating dietary patterns, nutritional status, and lifestyle factors.
- Incorporating nutritional assessment into statin management may improve tolerability, outcomes, and risk stratification beyond cholesterol-lowering strategies.