Bilateral Theta-Burst Stimulation of Dorsolateral Prefrontal Cortex Regions for Late-Life Depression: A Randomized, Sham-Controlled Clinical Trial - PubMed
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- #Geriatric Psychiatry
- #Depression
- #Neurostimulation
- Study assessed efficacy of theta-burst stimulation (TBS) for late-life depression.
- Randomized, triple-blind, sham-controlled clinical trial with 108 participants aged 60+.
- TBS was administered bilaterally to dorsolateral prefrontal cortex (DLPFC).
- No significant difference in HAM-D score reduction at week 6 between active and sham TBS.
- By week 12, active TBS showed greater reduction in HAM-D scores compared to sham.
- Response rates were 52% for active TBS vs. 33% for sham at week 12.
- TBS may be a viable treatment option for late-life depression.