Podocyte-Derived Extracellular Vesicles Induce Endothelial Dysfunction by Triggering ER Stress in Glomerular Disease - PubMed
3 hours ago
- #glomerular disease
- #ER stress
- #extracellular vesicles
- Podocyte injury and endothelial cell dysfunction are key features of glomerular disease.
- Extracellular vesicles (EVs) mediate communication between podocytes and endothelial cells.
- Injured podocytes release EVs enriched with integrin αvβ1.
- EVs trigger endothelial ER stress and apoptosis via FAK activation.
- Inhibition of integrin β1 signaling or EV secretion protects endothelial function.
- Targeted therapies blocking EV secretion or integrin αvβ1 may treat glomerular disease.