Activin A secretion by muscle-repairing macrophages induces heterotopic ossification in mice - PubMed
4 hours ago
- #muscle regeneration
- #macrophages
- #heterotopic ossification
- Macrophages play a key role in tissue repair, fibrosis, and tumorigenesis.
- Mrep (Ly6ChiCX3CR1loPDPN+CD9+) macrophages are crucial for muscle regeneration after injury.
- Muscle regeneration requires activin A, produced by Mrep macrophages via the TLR4/TIR/IRF3/7 signaling pathway.
- Mrep macrophages contribute to heterotopic ossification (HO) by secreting activin A.
- TLR4 inhibition can suppress HO, suggesting Mrep as a therapeutic target for muscle regeneration and HO suppression.