Fecal microbiota transplantation and Akkermansia muciniphila restore neurodevelopment and behavior via the gut-brain axis in autism-like zebrafish - PubMed
4 hours ago
- #Zebrafish Model
- #Microbiota-Gut-Brain Axis
- #Autism Spectrum Disorder
- Fecal microbiota transplantation (FMT) from wild-type donors and supplementation with Akkermansia muciniphila improved neurodevelopment and behavior in an autism-like zebrafish model.
- A. muciniphila colonized the gut, reshaped microbial communities, reduced anxiety-like behaviors, and modulated neurotransmitter-related gene expression.
- Mechanistic insights include upregulation of dopamine, serotonin, and GABA synthesis genes, downregulation of serotonin receptor htr3a, and enhanced SCFA receptor ffar2 expression.
- Microbiota from mutant zebrafish induced deficits in wild-type recipients, highlighting the gut-brain axis's role in neurodevelopmental impairments.
- The study supports the translational potential of microbiota-targeted interventions, particularly A. muciniphila, for autism spectrum disorder therapies.