The European distal renal tubular acidosis registry: a five-year analysis - PubMed

5 days ago

The European distal renal tubular acidosis (dRTA) registry collected prospective data from 2019 to 2024.
dRTA is characterized by metabolic acidosis, growth failure, nephrocalcinosis, nephrolithiasis, and chronic kidney disease (CKD).
214 patients were enrolled, with 22% being adults (>18 years) and 69% having a documented genetic cause.
Low blood bicarbonate levels (<22 mmol/L) and hypercalciuria were observed in 42% and 25% of patients, respectively.
Height standard deviation score (SDS) was positively associated with serum bicarbonate levels and early diagnosis.
Patients aged >30 years had significantly lower eGFR, and 36% had CKD ≥ stage 2.
Patients with SLC4A1 variants were at higher risk of CKD.
The study highlights the importance of metabolic control and suggests increasing blood bicarbonate levels to 24 mmol/L for improved growth.

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