Resting-State Functional Connectivity of the Amygdala and Hippocampus in PTSD: Results From the PGC-ENIGMA PTSD Working Group - PubMed
19 hours ago
- #Neuroimaging
- #Functional Connectivity
- #PTSD
- The study aimed to resolve inconsistent findings regarding resting-state functional connectivity (rs-FC) of the amygdala and hippocampus in PTSD.
- A mega-analysis of 32 international sites included 1,017 PTSD patients and 1,702 control participants.
- PTSD participants showed stronger rs-FC between the left amygdala and right hippocampus/amygdala, as well as lingual gyri.
- Greater PTSD severity scores correlated with increased rs-FC between the amygdala and hippocampus across hemispheres.
- The findings suggest heightened connectivity in threat-related neural networks involved in fear and memory processing in PTSD.
- Future research directions include exploring interventions like brain stimulation, neurofeedback, and psychotherapy to modulate these networks.