FOXA1 loss drives basal/squamous de-differentiation of prostate cancer and induces an immunosuppressive tumor microenvironment - PubMed
3 hours ago
- #Prostate Cancer
- #FOXA1
- #Immunosuppression
- FOXA1 loss in prostate cancer drives progression by shifting luminal cells to a basal/squamous-like state.
- This de-differentiation leads to an immunosuppressive tumor microenvironment with myeloid cell accumulation and dysfunctional T cells.
- FOXA1 normally represses basal/squamous and inflammatory genes, and its depletion activates these pathways.
- The study establishes FOXA1's tumor-suppressive role in maintaining luminal identity and preventing immunosuppression.