An update on the monogenic causes of Parkinson's disease: Impact on patient stratification and personalised medicine - PubMed
3 hours ago
- #Genetic mutations
- #Parkinson's disease
- #Personalized medicine
- Parkinson's disease (PD) has both genetic and environmental causes.
- Over 25 years, research has identified 26 PARK genes (e.g., SNCA, LRRK2, PRKN) with over 100 genetic variants linked to PD.
- These genetic mutations affect disease onset, progression, and treatment response.
- Monogenic discoveries help stratify patients and enable personalized medicine approaches.
- Emerging therapies include small molecules, antisense oligonucleotides, siRNA, CRISPR, and immunotherapies.
- Challenges remain in developing and equitably distributing these treatments globally.
- Ethical considerations and stakeholder engagement are crucial for equitable access.