Time-resolved functional genomics using deep learning reveals global hierarchical control of autophagy - PubMed
4 hours ago
- #deep learning
- #functional genomics
- #autophagy
- Study combines time-resolved high-content imaging, deep learning, and latent feature analysis to map the genetic network controlling autophagy activation and inactivation during nitrogen changes.
- Dataset AutoDRY categorizes 5,919 mutants based on nutrient response kinetics and their roles in autophagosome formation and clearance.
- Integration with functional and genetic network data reveals hierarchical and multilayered control of autophagy, uncovering new regulatory pathways.
- Identifies the retrograde pathway as a key time-varying modulator that regulates core autophagy genes and plays a central role in autophagy inactivation.
- Provides a systems-level resource for future autophagy research.