Genetic assessment of the causal relationship between obstructive sleep apnea and pulmonary hypertension: Mendelian randomization and meta-analysis - PubMed
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- #Obstructive sleep apnea
- #Mendelian randomization
- #Pulmonary hypertension
- Clinical observational studies suggest a complex association between obstructive sleep apnea (OSA) and pulmonary hypertension (PH), but the causal relationship is unclear due to confounding factors.
- A bidirectional two-sample Mendelian randomization (MR) analysis was conducted using pooled data from European population-based genome-wide association studies (GWAS) on OSA and PH.
- Statistical methods included inverse variance weighting (IVW), MR-Egger, weighted median, simple mode, and weighted mode, with IVW as the primary method.
- A meta-analysis of MR results showed a significant positive causal relationship between OSA and PH (OR = 1.20, 95% CI [1.01-1.43], P = 0.04).
- No significant negative causal relationship was observed (OR = 1.00, 95% CI [1.00-1.00], P = 0.99).
- Sensitivity analysis using MR-Egger, MR-PRESSO, and leave-one-out methods detected pleiotropy and heterogeneity.
- Genetically predicted OSA was significantly positively correlated with PH, but the underlying mechanism requires further investigation.