Nanodynamic Therapy in Colorectal Cancer: Engineering Precision Immunotherapy and Multimodal Synergy - PubMed
4 hours ago
- #nanodynamic therapy
- #immunotherapy
- #colorectal cancer
- Nanodynamic therapy (NDT) is a modular, energy-activated strategy that converts light, ultrasound, or electric fields into localized cytotoxic reactions for colorectal cancer treatment.
- NDT is guided by a 'Structure-Energy Conversion-Reaction Dynamics' framework, linking nanoplatform design to efficient energy conversion and controlled reactions, reducing off-target effects.
- CRC challenges include tumor heterogeneity, resistance, and relapse, which NDT addresses through intracavitary delivery for precise spatiotemporal control.
- Efficacy limitations of NDT alone, such as hypoxia and immunosuppressive microenvironments, drive its combination with immunotherapy and targeted interventions for synergy.
- Synergistic regimens integrate programmable NDT modules to induce immunogenic cell death and durable immune programming, enhanced by localized delivery systems like hydrogels or depots.
- Translational priorities for CRC-ready NDT platforms include patient stratification, clinical energy delivery, manufacturability, and overcoming tumor access barriers.