Estetrol-based combined oral contraceptives: A systematic review of clinical outcomes - PubMed
2 hours ago
- #systematic review
- #estetrol
- #contraceptives
- Systematic review examines safety and efficacy of estetrol (E4)-containing combined oral contraceptives (COCs) versus traditional COCs.
- E4-based COCs show high contraceptive reliability, predictable menstrual cycles, and favorable bleeding patterns.
- E4 COCs effectively suppress ovulation with rapid return after discontinuation and have milder effects on coagulation factors, suggesting reduced venous thromboembolism risk.
- Study limitations include design biases, small populations, short follow-up, and potential industry sponsorship; further independent research is needed.