LKB1-AMPK Signaling Pathway in Cardiovascular and Other Diseases - PubMed
3 hours ago
- #metabolic disorders
- #LKB1-AMPK
- #cardiovascular diseases
- The LKB1-AMPK signaling pathway is a key regulator of cellular energy homeostasis and stress adaptation.
- It coordinates glucose, lipid, and protein metabolism, maintaining physiological function across tissues.
- Dysregulation of this pathway is linked to cardiovascular diseases like atrial fibrillation, myocardial infarction, and atherosclerosis.
- The pathway is also involved in metabolic disorders (diabetes, diabetic nephropathy), neurodegenerative diseases (Alzheimer's, Parkinson's), and oncology.
- LKB1 mutations can drive tumorigenesis and affect therapeutic responses in cancer.
- Emerging therapeutic strategies include metformin, novel AMPK activators, and LKB1-based gene therapies.
- Challenges include tissue specificity, off-target effects, and genetic variation.
- The pathway has potential as a biomarker source and therapeutic target for precision medicine.