Linear and Nonlinear Associations Between Lipoprotein(a) and the Risks of Atherosclerotic Cardiovascular Disease - PubMed
4 hours ago
- #Mendelian randomization
- #Lipoprotein(a)
- #Atherosclerotic cardiovascular disease
- Lipoprotein(a) [Lp(a)] is a recognized risk factor for atherosclerotic cardiovascular disease (ASCVD).
- The study analyzed 351,858 UK Biobank participants to assess linear and nonlinear associations between Lp(a) levels and ASCVD risk.
- Higher Lp(a) levels were associated with increased ASCVD risk, with adjusted hazard ratios showing a graded relationship.
- Kaplan-Meier curves indicated early divergence in risk among different Lp(a) percentile groups.
- Spline models suggested nonlinearity in the association, with an inflection point near 130 nmol/L.
- Mendelian randomization (MR) analyses confirmed a causal association, showing a 2% higher ASCVD risk per 10 nmol/L increase in genetically predicted Lp(a).
- Nonlinear MR suggested steeper risk gradients at higher Lp(a) levels, though not statistically significant.
- The findings support routine Lp(a) measurement and the development of Lp(a)-lowering therapies.