Intracellular mitochondrial transfer in ischemic stroke: Mechanisms and therapeutic application - PubMed
4 hours ago
- #Mitochondrial transfer
- #Ischemic stroke
- #Stem cell therapy
- Therapeutic models for ischemic stroke (IS) are shifting from neuroprotection to cytoprotection, focusing on organelle transfer between cells.
- Intracellular mitochondrial transfer is an intrinsic response to IS, playing a critical role in mitigating neural damage.
- Mitochondrial transplantation from stem cells is emerging as a therapeutic avenue for IS.
- The review covers IS-induced mitochondrial dysfunction, modes of endogenous mitochondrial transfer, and stem cell-derived mitochondrial transplantation.
- Mitochondrial transfer has dual roles: health cells donate mitochondria to damaged cells, while damaged cells expel dysfunctional mitochondria.
- Enhancing healthy mitochondrial transfer or preventing damaged mitochondrial release may alleviate IS injury.