Tau catalyzes amyloid-β aggregation and toxicity in a polymorph-dependent manner - PubMed
4 hours ago
- #Alzheimer's disease
- #amyloid-β
- #tau protein
- Tau protein catalyzes amyloid-β (Aβ) aggregation and toxicity in a polymorph-dependent manner.
- Interactions between tau and Aβ worsen clinical outcomes in Alzheimer's disease (AD) and chronic traumatic encephalopathy (CTE).
- AD paired helical filament (PHF) and CTE tau folds catalyze Aβ42 nucleation with enzyme-like kinetics, with CTE fibrils showing the highest activity.
- PHF and CTE tau fibrils increase Aβ42 toxicity in neuroblastoma cells and transgenic C. elegans.
- The study highlights the role of amyloid structure in disease mechanisms and suggests potential for structure-based therapeutic design.