Applications of Carbon Dots and Graphene Quantum Dots in Treatment of Diabetes - PubMed
7 hours ago
- #carbon nanoparticles
- #diabetes treatment
- #drug delivery
- Carbon nanoparticles (CNPs) enhance anti-diabetic drugs like insulin, metformin, glimepiride, and vanadium compounds.
- Successful CNP carriers include carbon quantum dots (CQDs), graphene quantum dots (GQDs), graphene oxide quantum dots (GOQDs), hybrids, and fullerenes, typically ≤10 nm in size.
- Administration routes for CNPs in diabetes treatment include oral, intravenous, and implants in animal models.
- Pegylated GOQDs enhanced metformin efficacy by 500-1000 fold in in vitro insulin-resistant models.
- CNPs show low toxicity, protect loaded drugs, and are promising for targeted drug delivery, but further study on metabolism and processing is needed.