Time of Detection of Liver Metastases and Survival in Patients With Colorectal Cancer - PubMed
5 hours ago
- #colorectal cancer
- #liver metastases
- #survival analysis
- Study examines the association between the timing of colorectal cancer liver metastases (CRLM) detection and overall survival (OS) in patients.
- CRLM detection timing was categorized as synchronous, early metachronous, or late metachronous.
- Multicenter cohort study included 1250 patients from the Amsterdam Colorectal Liver Met Registry and the CAIRO5 trial (2000-2024).
- Synchronous CRLM was associated with worse OS compared to early and late metachronous CRLM in unadjusted analysis.
- After adjusting for tumor and treatment factors, timing of CRLM detection was not independently associated with OS.
- Findings suggest synchronicity reflects underlying tumor biology rather than directly influencing survival.
- Clinical decisions should consider synchronicity alongside tumor burden, variant status, and treatment strategy.