Immune reprogramming in the bone marrow microenvironment: a new perspective on the bone immune microenvironment of postmenopausal osteoporosis - PubMed
4 hours ago
- #postmenopausal osteoporosis
- #immune reprogramming
- #bone immunology
- Postmenopausal osteoporosis (PMOP) research traditionally focused on bone loss and remodeling imbalance.
- Immune reprogramming in the bone marrow microenvironment is a key driver of persistent bone loss in PMOP.
- Postmenopausal bone marrow microenvironment undergoes structural and functional changes, including myeloid bias in hematopoietic stem/progenitor cells and aging of BMSCs.
- Imbalance in immune cell subpopulations like M1/M2 macrophages and Th17/Treg cells is observed.
- Key signaling pathways involved include RANK/RANKL/OPG, Wnt/β-catenin, CXCL12-CXCR4, and S1P.
- Systemic factors like estrogen deficiency, inflammatory aging, and the gut-bone-immune axis shape the PMOP bone immune microenvironment.
- Proposed immunotherapy includes traditional bone-targeted drugs, immune-guided therapy, and comprehensive microenvironment intervention.
- Future research directions involve multi-omics, single-cell, and spatial omics for precise stratification and individualized intervention.