A randomized prospective study of neonatal hepatitis B vaccine immunogenicity in The Gambia and Papua New Guinea - PubMed
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- #neonatal vaccination
- #hepatitis B vaccine
- #immunogenicity
- Randomized prospective study on neonatal hepatitis B vaccine immunogenicity in The Gambia and Papua New Guinea.
- Aim to evaluate the impact of timing and sequence of HBV and BCG vaccines in the first week of life on infant HBV immunogenicity.
- Study involved 720 participants from The Gambia and 101 from Papua New Guinea, randomized into four vaccine groups.
- Blood samples collected at birth and on randomly assigned days (DOL1, DOL3, or DOL7) to measure anti-HBs titers.
- Maternal and neonatal baseline anti-HBs titers were strongly correlated.
- DOL0 titers predicted DOL30 titers but not DOL128 titers.
- Gambian infants receiving BCG at birth and HBV at DOL7 had higher DOL30 titers.
- PNG infants in the HBV + BCG group and the delayed group had higher DOL128 titers.
- Study highlights the importance of vaccine timing and maternal antibodies in early-life vaccine-induced immunogenicity.
- Demonstrates feasibility of large-scale neonatal immunogenicity studies in resource-constrained settings.